Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model Running title: Studying myeloid differentiation in mESC-based models
نویسندگان
چکیده
Department of Cell and Developmental Biology and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300200, China. Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, No.280, Chong-Qing South Road, Shanghai 200025, China. The Hebrew University–Hadassah Medical School, P.O. Box 12272, Jerusalem, 91120, Israel. Department of Pathology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA. Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
منابع مشابه
Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model.
Understanding the process of myeloid differentiation offers important insights into both normal and abnormal developmental processes but is limited by the dearth of experimental models. Here we show that myeloid progenitors can be derived from embryonic stem cells, immortalized, and applied to the study of the mechanisms underlying myeloid differentiation. The embryonic stem cell-derived myeloi...
متن کاملHEMATOPOIESIS AND STEM CELLS Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model
1Department of Cell and Developmental Biology and 2Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL; 3State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; 4Department of Pathophysiology, Shanghai Jiao-Tong University School of...
متن کاملExtracellular signal‑regulated kinase inhibition is required for methanol extract of Smilax china L.‑induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells.
Smilax china L., a well‑known Chinese traditional medicine, has been used as an anti‑inflammatory, anti‑cancer and analgesic agent, but its role has not yet been fully elucidated in oral mucoepidermoid carcinoma (MEC). The present study focused on addressing the anticancer activity and molecular mechanism of methanol extract of Smilax china L. (MESC) in MC‑3 human oral MEC cells. The results in...
متن کاملIdentification of Spata-19 New Variant with Expression beyond Meiotic Phase of Mouse Testis Development
Background: The study of specific genes expressed in the testis is important to understanding testis development and function. Spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. Spermatogenesis associated-19 (Spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. Its protein product is in...
متن کاملSpecialized mouse embryonic stem cells for studying vascular development
Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood. Here, we report the generation of the first dual reporter mouse embryonic stem cell (mESC) lines designed to facilitate the study of vascular endothelial and smooth muscle development in vitro. Thes...
متن کامل